Cluster IV: Molecular Biology of P - The central Role of P in Signaling and Metabolism from Cells to Ecosystems
The overarching goal is to unravel the central role of P as a metabolic, signaling and regulatory molecule from molecular to ecosystem levels. In fact, P acquisition, mobilisation and assimilation involve various molecular mechanisms in microorganisms, plants and animals. Moreover, P plays a key role in signalling at the level of ecosystems, organisms and cells. Projects in this Cluster aim to analyse the molecular mechanisms related to the uptake of P from the environment into the organism, the distribution, storage and mobilisation of P within the organisms and its essential roles in the cellular metabolism as well as in the crosstalk of microorganisms, cells and tissues.
Anschubprojekte im Rahmen der Förderung des Leibniz-WissenschaftsCampus Phosphorforschung Rostock (WGL, ab 07/2019)
Baclofen: Entwicklung effizienter Produktionsverfahren für die Darstellung von Baclofen und hiermit verwandter pharmazeutischer Produkte (BMWi, AIF, 01/2020-09/2023)
Graduiertenschule II: Leibniz-WissenschaftsCampus Phosphorforschung Rostock (WGL, 07/2019-06/2023)
MitoBOX: The mitochondrial basis of hypoxia tolerance in marine mollusks (DFG, 02/2019-01/2022)
2021
Oster, M., Reyer, H., Gerlinger, C., Trakooljul, N., Siengdee, P., Keiler, J., Ponsuksili, S., Wolf, P., Wimmers, K. (2021): mRNA Profiles of Porcine Parathyroid Glands Following Variable Phosphorus Supplies throughout Fetal and Postnatal Life. Biomedicines 9 [454]: 1-14, DOI: 10.3390/biomedicines9050454
Ponsuksili, S., Hadlich, F., Reyer, H., Oster, M., Trakooljul, N., Iqbal, M.A., Sommerfeld, V., Rodehutscord, M., Wimmers, K. (2021): Genetic background and production periods shape the microRNA profiles of the gut in laying hens. Genomics 113 [4]: 1790-1801, DOI: 10.1016/j.ygeno.2021.04.018
2020
Falfushynska, H.I., Sokolov, E., Piontkivska, H., Sokolova, I. (2020): The Role of Reversible Protein Phosphorylation in Regulation of the Mitochondrial Electron Transport System During Hypoxia and Reoxygenation Stress in Marine Bivalves. Frontiers in Marine Science 7: 467, DOI: 10.3389/fmars.2020.00467
Gussone, N., Böttcher, M.E., Conrad, A.C., Fiebig, J., Pelz, M., Grathoff, G., Schmidt, B.C. (2020): Calcium isotope fractionation upon experimental apatite formation. Chemical Geology 551: 119737, DOI: 10.1016/j.chemgeo.2020.119737
Oster, M., Reyer, H., Trakooljul, N., Weber, F. M., Xi, L., Muráni, E., Ponsuksili, S., Rodehutscord, M., Bennewitz, J., Wimmers, K. (2020): Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization. International Journal of Molecular Sciences 21, 2762:, DOI: 10.3390/ijms21082762
Ponsuksili, S., Reyer, H., Hadlich, F., Weber, F., Trakooljul, N., Oster, M., Siengdee, P., Muráni, E., Rodehutscord, M., Camarinha-Silva, A., Bennewitz, J., Wimmers, K. (2020): Identification of the Key Molecular Drivers of Phosphorus Utilization Based on Host miRNA-mRNA and Gut Microbiome Interactions. International Journal of Molecular Sciences 21, 2818:, DOI: 10.3390/ijms21082818
Siengdee, P., Oster, M., Reyer, H., Viergutz, T., Wimmers, K., Ponsuksili, S. (2020): Morphological and Molecular Features of Porcine Mesenchymal Stem Cells Derived From Different Types of Synovial Membrane, and Genetic Background of Cell Donors. Frontiers in Cell and Developmental Biology 8: 601212, DOI: 10.3389/fcell.2020.601212
Zwicker, J., Smrzka, D., Steindl, F., Böttcher, M.E., Libowitzky, E., Kiel, S., Peckmann, J. (2020): Mineral authigenesis within chemosynthetic microbial mats: Coated grain formation and phosphogenesis at a Cretaceous hydrocarbon seep, New Zealand. The Depositional Record 6:, DOI: 10.1002/dep2.123
2019
Hagemann, M., Möke, F., Springer, A., Westermann, L., Frank, M., Wasmund, N., Bauwe, H. (2019): Cyanobacterium Nodularia spumigena strain CCY9414 accumulates polyphosphate under long-term P-limiting conditions. Aquatic Microbial Ecology 82: 265-274, DOI: 10.3354/ame01896
Haider, F., Sokolov, E.P., Timm, S., Hagemann, M., Blanco Rayón, E., Marigómez, I., Izagirre, U., Sokolova, I. (2019): Interactive effects of osmotic stress and burrowing activity on protein metabolism and muscle capacity in the soft shell clam Mya arenaria. Comparative Biochemistry and Physiology 228: 81–93, DOI: 10.1016/j.cbpa.2018.10.022
Jung., P., Schermer, M., Briegel-Williams, L., Baumann, K., Leinweber, P., Karsten, U., Lehnert, L., Achilles, S., Bendix, J., Büdel, B. (2019): Water availability shapes edaphic and lithic cyanobacterial communities in the Atacama Desert. Journal of Phycology 55: 1306-1318, DOI: 10.1111/jpy.12908
Löffler, N., Fiebig, J., Mulch, A., Tütken, T., Schmidt, B.C., Bajnai, D., Conrad, A.C., Wacker, U., Böttcher, M.E. (2019): Refining the temperature dependence of the oxygen and clumped isotopic compositions of structurally bound carbonate in apatite. Geochimica et Cosmochimica Acta 253: 19-38, DOI: 10.1016/j.gca.2019.03.002
Reyer, H., Oster, M., Wittenburg, D., Muráni, E., Ponsuksili, S., Wimmers, K. (2019): Genetic Contribution to Variation in Blood Calcium, Phosphorus, and Alkaline Phosphatase Activity in Pigs. Frontiers in Genetics 10:590:, DOI: 10.3389/fgene.2019.00590
Sokolov, E.P., Markert, S., Hinzke, T., Hirschfeld, C., Becher, D., Ponsuksili, S., Sokolova, I.M. (2019): Effects of hypoxia-reoxygenation stress on mitochondrial proteome and bioenergetics of the hypoxia-tolerant marine bivalve Crassostrea gigas. Journal of Proteomics 194: 99-111, DOI: 10.1016/j.jprot.2018.12.009
Sokolova, I., Sokolov, E.P., Haider, F., (2019): Mitochondrial Mechanisms Underlying Tolerance to Fluctuating Oxygen Conditions: Lessons from Hypoxia-Tolerant Organisms. Integrative and Comparative Biology 59: 938-952, DOI: 10.1093/icb/icz047
Sokolov, E.P., Sokolova, I.M. (2019): Compatible osmolytes modulate mitochondrial function in a marine osmoconformer Crassostrea gigas (Thunberg, 1793). Mitochondrion 45: 29-37, DOI: 10.1016/j.mito.2018.02.002
Wubuli, A., Reyer, H., Muráni, E., Ponsuksili, S., Wolf, P., Oster, M., Wimmers, K. (2019): Tissue-Wide Gene Expression Analysis of Sodium/Phosphate Co-Transporters in Pigs. International Journal of Molecular Sciences 20, 5576:, DOI: 10.3390/ijms20225576
2018
Steinbauer, J., Kubis, C., Ludwig, R., Werner, T. (2018): Mechanistic Study on the Addition of CO2 to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach. ACS Sustainable Chemistry and Engineering 6: 10778–1078, DOI: 10.1021/acssuschemeng.8b02093.s001
| Linda Adzigbli | MNF | Institut für Biowissenschaften, Meeresbiologie |
| Masuf Hasan | FBN | Genombiologie |
| Sandra Kammann | MNF | Institut für Biowissenschaften, Angewandte Ökologie und Phykologie |
| Prof. Dr. Ulf Karsten | MNF | Institut für Biowissenschaften, Angewandte Ökologie und Phykologie |
| PD Dr. Matthias Labrenz | IOW | Umweltmikrobiologie |
| Prof. Dr. Cornelia C. Metges | FBN | Institut für Ernährungsphysiologie 'Oskar Kellner' |
| Dr. Michael Oster | FBN | Genombiologie |
| Mariano Santoro | IOW | Umweltmikrobiologie |
| Dr. Evgeny Sokolov | IOW | Direktorat |
| Prof. Dr. Inna Sokolova | MNF | Institut für Biowissenschaften, Meeresbiologie |
| Prof. Dr. Klaus Wimmers | FBN | Genombiologie |
| PD Dr. Siriluck Wimmers | FBN | Genombiologie |